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Project summary

Cardiovascular diseases (CAD) are one of the main causes of mortality and morbidity in most developed countries, and they are among the multifactorial pathologies with high priority in the Sixth Framework Program. Recent technological advances have greatly increased the capability to investigate the complex interactions that occur in this and several other diseases. Moreover,the capability to identify genetic alterations has opened a new scenario for the screening of several new drugs. The first critical step of the drug development process is the identification and the validation of drug targets (e. g. proteins, nucleic acids) for therapeutic applications. The target identification is essential to screen and synthesize new bioactive molecules that can interact with them. The screening of targets is extremely difficult for multifactorial diseases, which are characterized by complex synergies between genetic and environmental factors. Cardiovascular diseases (CAD) are one of the major group of multifactorial diseases and are one the main causes of mortality and morbidity in most developed countries. The Aim of this project is to discover new factors involved in ischemic failures and in their related CAD and set up systems to select and test molecules that are pharmacologically active for the treatment of CAD.

For more details see Project Objective
Figure 1 - Project flowchart. Dotted lines show data flow from experimental activities; continuous lines show data flow from computational activities.